The LC-2010 is a completely integrated chromatography system. It comprises a quaternary gradient low-pressure mixing pump with integral degasser, autosampler, column oven, dual-wavelength UV-Vis detector and system controller in one ultra-small footprint. Available in both Peltier cooled and ambient autosampler versions, the LC-2010 has set new standards in precision, throughput and regulatory compliance.

LC-2010 is an integrated HPLC system full of the most advanced technologies; provides you with high performance and useful functions which help you do chromatography more productively.

Higher Speed. Higher capacity -- Never-ending desire for High Throughput is addressed by the Autosampler. High speed of injection (15 sec for 10 µL injection) for 4 MTP, standard or Deep-well plate cooling capability in a compact footprint provides you with up to 1536 unattended analyses ! In addition to rapid throughput, the system provides more robust, durable and reproducible injection capability.

Automation frees you from repetitious daily operations, such as changing mobile phases, waiting for the baseline stability, and rinsing the column after analyses by automated these functions. Automated standalone system operation provides the estimated ending time of the analyses, amount of remaining mobile phases.

A High level validation is mandated in order to comply with GLP/GMP requirements. The time, effort and increased costs to meet these requirements are now addressed by the automated validation and verification of the operation of the overall system. Also CMD (Column Management Device) enables users to manage the column history and term of validity.

For most users, analytical equipment is just another tool. If that tool is difficult to operate or requiring a steep learning curve, no benefit can be gained no matter how numerous its capabilities. Graphical operating screens and wizard functions make it simple to use even for the first time user. Moreover, users can run gradient analyses as well as isocratic analyses even more easily by using Simple Mode of operation.

The CoSense Series is an automated sample pre-treatment system designed to facilitate the processing of complex samples and augment the efficiency of NMR and MS measurements. HPLC column switching is used to separate, purify and concentrate target compounds as well as perform desalting and solvent replacement.

The process of purifying target compounds from the sample, including concentration, desalting and (most importantly) deuterated solvent replacement is completely automated on CoSense for NMR. Manual handling of large quantities of expensive deuterated solvents is entirely eliminated, shortening analysis times and reducing costs.

While LC-NMR and LC-MS are useful analytical methods, for the structural analysis of compounds, the conditions most often used for HPLC are not optimum for NMR or MS. For that reason, analysis of samples in a complex matrix require cumbersome procedures involving initial separation-purification using HPLC, followed by desalting and other processes before NMR/MS analysis can be performed.

Co-Sense LC-NMR / LC-MS is an automated sample pretreatment system designed to facilitate the processing of complex samples and augment the efficiency of NMR and MS measurements. HPLC column-switching technology is used to separate, purify and concentrate target compounds, and perform desalting and solvent replacement. This eliminates the bother and expense of performing such operations manually. Further, the separation of target compounds using HPLC is not limited by NMR and MS restrictions, allowing HPLC parameter selection as desired.

System is designed for LC-NMR and LC-MS sample preparation. After a semi-preparative or analytical separation the peaks can be collected and pre-concentrated on a trap column to reach the necessary concentration for an NMR analysis. The expansive D²-solvents will be used only in the last step, when the samples are re-eluted after trapping. Full automation allow online or offline measurements and can reduce the time for manual preparation.

For LCMS use the separation can be done with typical high concentrated buffers, the solvents will be exchanged direct before the LCMS inlet. Especially if LCMS is not the standard method and is asked to confirm the results of other techniques this could be an alternative, because validated methods are not need to change.

Problems associated with non-volatile buffers or compromised LC separations arising from running solvents best for MS analysis are prevented with the CoSense for MS. Optimum separations can be run, with target compounds being purified, concentrated, desalted and re-eluted into the MS in a suitable volatile solvent system.

While LC-NMR and LC-MS are useful analytical methods, for the structural analysis of compounds, the conditions most often used for HPLC are not optimum for NMR or MS. For that reason, analysis of samples in a complex matrix require cumbersome procedures involving initial separation-purification using HPLC, followed by desalting and other processes before NMR/MS analysis can be performed.

Co-Sense LC-NMR / LC-MS is an automated sample pretreatment system designed to facilitate the processing of complex samples and augment the efficiency of NMR and MS measurements. HPLC column-switching technology is used to separate, purify and concentrate target compounds, and perform desalting and solvent replacement. This eliminates the bother and expense of performing such operations manually. Further, the separation of target compounds using HPLC is not limited by NMR and MS restrictions, allowing HPLC parameter selection as desired.

System is designed for LC-NMR and LC-MS sample preparation. After a semi-preparative or analytical separation the peaks can be collected and pre-concentrated on a trap column to reach the necessary concentration for an NMR analysis. The expansive D²-solvents will be used only in the last step, when the samples are re-eluted after trapping. Full automation allow online or offline measurements and can reduce the time for manual preparation.

For LCMS use the separation can be done with typical high concentrated buffers, the solvents will be exchanged direct before the LCMS inlet. Especially if LCMS is not the standard method and is asked to confirm the results of other techniques this could be an alternative, because validated methods are not need to change.

Utilising the unique and newly developed MAYI-ODS on-line SPE column and dilution flow channel, the Bioanalysis CoSense seamlessly conducts all processes from sample pre-treatment to analysis. Automatic, On-line pre-treatment of biological samples such as serum or plasma minimises handling and enhances application efficiency.

Co-Sense for BA features the dilution bypass added in the sample introduction flow channel leading to the MAYI pretreatment columns. Different type of MAYI columns enable to use this approach for various type of components. This dilution bypass eliminates the need for preliminary dilution of the sample by automatically diluting it on-line. Use of a buffer solution as the sample introduction mobile phase or adding a small amount of organic solvent to it ensures effective trapping and concentration of even drugs with a high rate of protein binding, leading to highly efficient deproteinisation and a high recovery rate. Thus, direct injection of unprocessed blood plasma or blood serum has become possible.

HPLC is widely employed in the analysis of drugs within bio-samples. Conditions of the sample pretreatment, as well as chromatographic conditions, are important factors that significantly affect the accuracy and sensitivity of the analysis. Co-Sense for BA, with its unique configuration comprised of the newly developed MAYI-ODS on-line SPE column and the on-line dilution flow channel, automatically and seamlessly conducts all processes from sample pretreatment to analysis. On-line pretreatment of bio-samples such as blood serum or plasma will remarkably enhance the efficiency, as well as reduce the labor, of the analysis.

Cleaning validation of manufacturing equipment involved in pharmaceutical production is an essential factor in GMP. CoSense for CV addresses the needs for a highly sensitive yet simple method for sample pre-treatment, analysis and residue evaluation. Wizard navigation with authorisation levels allow intuitive, secure operation.

Cleaning validation of manufacturing equipment involved in pharmaceutical production is an essential factor in GMP. However, it requires complicated and laborious processes such as sampling from the equipment, sample pretreatment, analysis of the compound concerned, and evaluation of the residue amount. Setting the threshold values, which have to be determined taking into consideration various factors such as the effective amount and dosage of the medicine, the size of the production batch, and the size of the equipment, is also a difficult procedure. The Co-Sense CV is an HPLC application system addressing this demand. The unique system configuration and special software dramatically enhance the efficiency of cleaning validation by automatically conducting all processes from sample concentration to analysis and data processing.

A column-switching technique is used to concentrate the target component within the sample onto the concentration column, then send it to the analysis column for separation and detection. Complex sample pretreatment is therefore unnecessary, as the target component is concentrated from a large amount of sample, even a trace amount of component can be detected with high sensitivity.

The target component is concentrated while diluting the sample by any desired rate, assuring creation of a clear peak, as well as a high recovery rate regardless of the type of the sample solvent used for extraction (patent pending).