LCMS-2010EV (Evolution) refined and enhanced for even higher sensitivity in mass spectrometry detection.

Key features

• Revised ion source design. Orthogonal source geometry with an additional drying gas at the inlet of the capillary. Results in higher sensitivity and greater control of solvent adduct formation.
• Revised electrospray probe design. Maintenance free design.
• Revised ion optics. Enhanced ion transmission by further optimising the skimmer cone design at the entrance to the mass analyser.
• Microbore compatibility for both ESI and APCI. Technological advances in probe design have expanded the operating range of both APCI and ESI without affecting sensitivity. APCI is now compatible with microbore flow rates (less than 50uL/minute) while ESI can operate with flow rates as high as 2mL/minute without requiring flow splitting
• Mass directed purification support. PsiPort™ mass directed auto-purification software has been designed to help accelerate compound isolation and auto-purification by preparative LC/MS. The application software is web-based providing a generic solution to data review and data acquisition and has been designed to meet the needs of medicinal and synthetic chemists to track samples, fractions and associated data from MS and UV detectors. PsiPort™ also supports third party devices such as the Gilson 215 either as a fraction collector or autosampler.
• Fast scanning electronics support 6000 amu/second (6000 data points per second) acquisition rates for fast chromatography applications. Peak widths of several seconds may be detected using fast scan rates to maintain spectrum quality without affecting the accuracy and precision of detection.
• Multi-sequence mode support. Supports mixed mode analysis (switching between full scan acquisitions and selected ion monitoring), multiple acquisition conditions in a single analysis, simultaneous structural information and molecular weight confirmation in both positive and negative ion mode from a single injection and optimizes the response to both quantitation ions and confirmatory ions to minimize false positives and increase confidence in peak assignment.
• Automatically controlled nebulizer gas flow.
• Software-controlled syringe pump for simple calibration and infusion.
  Unique Q-array™ (patent pending) ion guide. Q-array ion guide (patent pending) configuration is unique - three quadrupoles with different inscribed radii coupled with an octapole The Q-array™ precisely focuses ion delivery into the mass analyser. The ion optic design for the LCMS-2010EV is the most innovative design in ion focussing technology. Using the Q-array™ (patent pending) and octapole RF guides to precisely focus ions to the mass analyser we deliver new limits of detection for LC.
  

Unmatched productivity

• Supports the new standard in high throughput auto-injectors, the SIL-HT from Shimadzu (15 second injection cycle)
• Automatic acquisition, processing and reporting through a single click of the mouse
  High throughput micro-titre plate support.
• Customised reporting for efficient and effective information management.
• Streamlined data processing for third party software systems
• Automated export to knowledge systems.
• Mass directed purification.

Multi-sequence mode

• Enhanced source design
• The atmospheric pressure ion source now supports a counter gas flow to control adduct formation and enhance ion transmission of low polarity compounds. The counter gas flow not only enhances the desolvation processes but reduces the maintenance on the capillary inlet.
• To reduce maintenance further and increase sensitivity the electrospray probe design has also been redesigned to take into account a stainless steel capillary.

The LCMS-2010 Evolution provides superb high throughput performance mass detection in a flexible compact package. The system is supplied with an ESI probe, integrated autotuning and infusion capability as standard. The system may be seamlessly expanded by the addition of high performance APCI and APPI probes, or the switching valve/flow injection options. Productivity is maximised by the intelligent use of multi-sequence modes enabling simultaneous data collection for up to 64 combined experiments. The instrument can be configured to operate as a modular system, or combined with the innovative LC 2010HT standalone LC to provide an ‘end of bench' LCMS detector. The SIL-HT and LC10Advp modules offers low carry over and high through put with supreme gradient performance from the microlitre flow range upwards. When teamed with the LC 2010HT the LCMS-2010EV provides a completely integrated ‘normal' flow range LCMS in less than a metre of bench space – the smallest footprint of any single Quadrupole LCMS instrument.

PsiPort Browser is a web-based LCMS software package that enables multi-user laboratories to increase productivity and sample throughput with minimal training requirements for both preparative and analytical experiments.

PsiPort Direct Access is the 'walk-up' feature of PsiPort Browser that allows users to log analytical samples using a minimum number of mouse clicks.

Main PsiPort features:

- Four separate user access levels - Admin, Power User, User, Guest
- Project-based organization - users only have access to methods within their assigned projects
- Can be accessed by an unlimited number of users from any client PC through Internet Explorer - monitor analyses and review data remotely
- Supports MS, UV, PDA, and analog devices (ex: ELSD)
- Data-dependent browser - clicking on a sample/fraction vial links to the associated MS and LC data
- Evaluates sample purity
- Up to 10 target masses supported
- Supports both SIM and Scan modes
- E-mail notification of completed runs
- Automatic fraction reports generated

For increased sample capacity and flexibility, Instrument Control software provides full control over the Gilson 215 Liquid Handler as an autosampler or a fraction collector or both within the same instrument. All drivers are included - there is no need to purchase Gilson's Unipoint software.

Functioning as a module of LCsolution software, LCMSsolution provides complete access to the analytical power of the mass spectrometer, without compromising its ease of use as an LC detector. Truly integrated chromatogram and spectral processing, with a powerful quantification package and unsurpassed flexibility in reporting; operating in a true 32 bit environment.

Excellent wizards guide the unaccustomed user through all aspects of instrument and sample set up. Alternatively the experienced user can rapidly access all necessary parameters directly. Innovative ‘browser' software gives rapid and effective access to multiple data files in either qualitative or quantitative screening applications.

For the multi-user environment there is full and effective control of user rights via password protection, simple data export and comprehensive audit trailing (with the optional Class Agent software package).

• Flexible LC Systems & modules
• LC Software & Control