LCMS-2010EV (Evolution) refined and enhanced for even higher sensitivity in mass spectrometry detection.

Key features

• Revised ion source design. Orthogonal source geometry with an additional drying gas at the inlet of the capillary. Results in higher sensitivity and greater control of solvent adduct formation.
• Revised electrospray probe design. Maintenance free design.
• Revised ion optics. Enhanced ion transmission by further optimising the skimmer cone design at the entrance to the mass analyser.
• Microbore compatibility for both ESI and APCI. Technological advances in probe design have expanded the operating range of both APCI and ESI without affecting sensitivity. APCI is now compatible with microbore flow rates (less than 50uL/minute) while ESI can operate with flow rates as high as 2mL/minute without requiring flow splitting
• Mass directed purification support. PsiPort™ mass directed auto-purification software has been designed to help accelerate compound isolation and auto-purification by preparative LC/MS. The application software is web-based providing a generic solution to data review and data acquisition and has been designed to meet the needs of medicinal and synthetic chemists to track samples, fractions and associated data from MS and UV detectors. PsiPort™ also supports third party devices such as the Gilson 215 either as a fraction collector or autosampler.
• Fast scanning electronics support 6000 amu/second (6000 data points per second) acquisition rates for fast chromatography applications. Peak widths of several seconds may be detected using fast scan rates to maintain spectrum quality without affecting the accuracy and precision of detection.
• Multi-sequence mode support. Supports mixed mode analysis (switching between full scan acquisitions and selected ion monitoring), multiple acquisition conditions in a single analysis, simultaneous structural information and molecular weight confirmation in both positive and negative ion mode from a single injection and optimizes the response to both quantitation ions and confirmatory ions to minimize false positives and increase confidence in peak assignment.
• Automatically controlled nebulizer gas flow.
• Software-controlled syringe pump for simple calibration and infusion.
  Unique Q-array™ (patent pending) ion guide. Q-array ion guide (patent pending) configuration is unique - three quadrupoles with different inscribed radii coupled with an octapole The Q-array™ precisely focuses ion delivery into the mass analyser. The ion optic design for the LCMS-2010EV is the most innovative design in ion focussing technology. Using the Q-array™ (patent pending) and octapole RF guides to precisely focus ions to the mass analyser we deliver new limits of detection for LC.
  

Unmatched productivity

• Supports the new standard in high throughput auto-injectors, the SIL-HT from Shimadzu (15 second injection cycle)
• Automatic acquisition, processing and reporting through a single click of the mouse
  High throughput micro-titre plate support.
• Customised reporting for efficient and effective information management.
• Streamlined data processing for third party software systems
• Automated export to knowledge systems.
• Mass directed purification.

Multi-sequence mode

• Enhanced source design
• The atmospheric pressure ion source now supports a counter gas flow to control adduct formation and enhance ion transmission of low polarity compounds. The counter gas flow not only enhances the desolvation processes but reduces the maintenance on the capillary inlet.
• To reduce maintenance further and increase sensitivity the electrospray probe design has also been redesigned to take into account a stainless steel capillary.

The LCMS-2010 Evolution provides superb high throughput performance mass detection in a flexible compact package. The system is supplied with an ESI probe, integrated autotuning and infusion capability as standard. The system may be seamlessly expanded by the addition of high performance APCI and APPI probes, or the switching valve/flow injection options. Productivity is maximised by the intelligent use of multi-sequence modes enabling simultaneous data collection for up to 64 combined experiments. The instrument can be configured to operate as a modular system, or combined with the innovative LC 2010HT standalone LC to provide an ‘end of bench' LCMS detector. The SIL-HT and LC10Advp modules offers low carry over and high through put with supreme gradient performance from the microlitre flow range upwards. When teamed with the LC 2010HT the LCMS-2010EV provides a completely integrated ‘normal' flow range LCMS in less than a metre of bench space – the smallest footprint of any single Quadrupole LCMS instrument.

The SPD-M20A High Performance Liquid Chromatography PDA detector provides users with the most advanced level of sensitivity and stability found in today's PDA detectors. Sharing many of the qualities of the SPD-20A/20AV UV-Vis Detectors, the SPD-M20A attains sensitivity levels approaching the most advanced UV-Vis detectors. It has a high-sensitivity mode with an 8 nm slit width. Using light-source compensation, it offers a noise level of 0.6×10-5 AU, which is comparable to that of traditional UV-VIS detectors.

Features

Greater Baseline Stability
Supplied as standard, a temperature-controlled flow cell eliminates inconsistencies caused by changes in absorbance due to shifts in room temperature. This helps increase the baseline stability and the analysis reliability.

Superior Linearity - 2.0AU
Using newly developed signal processing technology, the stray-light correction function has been enhanced, and the linearity has been improved. This expanded linearity combines with various noise-reduction technologies to provide users with a wide dynamic range and allow for the analysis of your target compound and minor impurities in a single run.

Web Browser Control
The SPD-M20A is equipped with an Ethernet interface and Web-control functions, allowing devices to be monitored and controlled from PCs in the network. As a standalone high-sensitivity multi-wavelength detector, it can be incorporated into non-Shimadzu HPLC systems.

Low Temperature Evaporative Light Scattering Detector

Enhanced Sensitivity for Trace Analysis

The ELSD-LTII utilizes a high-efficiency LED and enhanced digital signal treatment to minimize noise and deliver optimum sensitivity for trace analysis. An innovative cell design also reduces band broadening and allows sensitivity levels below 200 picograms. The high-performance optical detection system can also be used for combinatorial chemistry and high-throughput screening applications.

he new Low Temperature Evaporative Light Scattering Detector (ELSD-LTII) is an easy-to-operate, universal detector that identifies analytes with uniform sensitivity regardless of their spectroscopic properties. It is not a spectroscopic detector. Instead, it removes the mobile phase through evaporation and then makes a light scattering measurement of the dried analyte particles.

Features

The ELSD-LTII is ideally suited for such applications as drug discovery, natural products development, combinatorial chemistry, and food and beverage. It will enable you to see all sample components, even semi-volatile compounds, down to the high picogram level.

The ELSD-LTII provides excellent performance during gradients for optimized separations and reduced run times. A unique cell design reduces band broadening to a level similar to UV-Vis detectors while its single mode, low-temperature operation (user defined from ambient 80°C) optimizes sensitivity for those analytes that are easily missed at higher evaporation temperatures typical of competing detectors.

Very selective and very sensitive, electrochemical detection is the first choice for those involved in neuroscience or clinical diagnostics.The technique is also very sensitive to pulsation and metal ion leaching from the rest of the LC system, and so the high quality and low pulsation of Shimadzu systems compliments this detection method. Whilst traditionally having very specialised applications, electochemical detection has recently found another complimentary role in enhancing or modifying ionisation in LC-MS.

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