MALDI-8020

A true multi‒user high‒performance MALDI TOF‒TOF Mass Spectrometer

The MALDI‒8020 is the latest in a long line of MALDI‒TOF products from Shimadzu. This benchtop, linear MALDI‒TOF mass spectrometer delivers outstanding performance in a compact footprint, making it an ideal choice for today’s increasingly demanding laboratories. 

  • Linear mode (positive ion) MALDI‒TOF
  • 200 Hz solid‒state laser, 355 nm
  • Load‒lock chamber for fast sample introduction
  • UV laser‒based source cleaning (patented)
  • Small footprint/benchtop design
  • Quiet operation (<55 dB)

Compatible with the FlexiMass™ series of microscope slide-format sample targets, these slides provide researchers with options depending on their experimental workflow.

Ready-to-use, these disposable targets eliminate the need for cleaning and the risk of carryover. Alternatively, the reusable stainless steel FlexiMass™-SR sample targets provide a cost-effective, longer-term solution to sample preparation.

Linear mode instruments have traditionally been the instruments of choice in MALDI‒TOF‒based quality control (QC) and profiling workflows, and the MALDI‒ 8020 is no exception. Peptides, proteins, polymers or oligonucleotides ‒ the instrument is capable of delivering the performance required for QC applications. Research laboratories will also benefit from the MS capabilities of the instrument through the rapid mass‒measurement of samples.

TrueClean™ automated source cleaning

To maintain instrument performance over time, the MALDI-8020 features wide-bore ion optics - a feature used on our existing MALDI-TOF products - which minimize the risk of source contamination over time, providing a robust platform. To maximize uptime, the system is equipped with TrueClean - an automated, rapid (<10 min) UV laser-based source cleaning which can be used to clean the extraction electrode in-situ without breaking instrument vacuum.

Quality as standard

As mass spectrometry moves into clinical laboratories, the MALDI-8020 is the perfect choice for researchers developing MALDI-based diagnostic methods†.

The system is designed and manufactured to ISO 9001:2015 and ISO 13485:2016 quality management standards and is CE compliant. Through the selection of components demonstrating improved longevity and performance, and by reducing the number of component parts, our engineers have created a reliable and robust platform capable of delivering outstanding performance in a small footprint.

The MALDI systems are maintained by trained service support engineers who form part of the Shimadzu global distribution and support network. Routine maintenance is simplified thanks to the instrument design, providing our engineers with easy access to commonly serviced parts. † For Research Use Only. Not for use in diagnostic procedures.

Example of higher mass analysis using immunoglobulin A (IgA)

Polymer analysis: polycarbonate from a CD (green spectrum) and polycarbonate standard (orange spectrum).
Inset: expanded view of the highlighted region.

Analysis of chlorhexidine gluconate in mouthwash solution. Sample was prepared with MALDI matrix without any clean-up or dilution.

Inset: expanded view showing peak at m/z 505.2

Related Applications

Protein Identification from Two-dimensional Gel Electrophoresis Based on Peptide Mass Fingerprinting (PMF) Using a Benchtop MALDI-TOF Mass Spectrometer

Synthesis Confirmation for Nucleic Acid Medicines - Rapid Sequence Confirmation Using a MALDI-TOF Mass Spectrometer

Rapid Measurement of Low-molecular Compounds Using a Benchtop MALDI-TOF Mass Spectrometer - Direct Detection of Antiseptic Components in Oral Care Products

Protein Sequence Analysis by In-Source Decay Using a Benchtop MALDI-TOF Mass Spectrometer

Analysis of Polycarbonate Using a Benchtop MALDI-TOF Mass Spectrometer

Molecular Weight Measurement of Glycoproteins Using a Benchtop MALDI-TOF Mass Spectrometer

Surface Analysis of PET Film Using a Benchtop MALDI-TOF Mass Spectrometer

Analysis of Phosphoproteins Using a Benchtop MALDI-TOF Mass Spectrometer

Detection of High-mass Proteins Using a Benchtop MALDI-TOF Mass Spectrometer

Facilitates 21 CFR Part 11 compliance

Operating under the control of MALDI SolutionsTM software, the software features a centralized, secure Microsoft* SQL database which can be used to store everything from sample lists and acquisition Parameter Sets to acquired MALDI data. The system is managed by an Administrator and customizable user profiles provide control over access to the database and operation of the instrument. Along with a full audit trail, the software provides the tools to help achieve 21 CFR part 11 regulatory compliance.
* Microsoft® is trademark of Microsoft Corporation in the United States. Other company names and product names mentioned are trademarks or registered trademarks of their respective companies.

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