Automated Immunosuppressant Analysis
Use the DOSIMMUNE kit as your turnkey solution for automated immunosuppressant analysis!
An efficient and time-saving new method using an optimised and fully compliant combination of instruments, reagents and software now exists for high-throughput analysis of immunosuppressants.
Immunosuppressant drugs are used to reduce the activity of the immune system to prevent transplant rejection. In order to avoid overdosing, which can cause serious toxicity and long-term morbidity, a narrow therapeutic concentration window is required of these major drugs. Underdosing is equally as problematic, for fear of graft rejection. Analysis of these drugs is known as therapeutic drug monitoring (TDM), and aims to maximise drug efficacy and minimise side effects to patients.
A combination of LC-MS/MS with liquid handlers provides a robust, reliable and automated approach to perform TDM. Additionally, the DOSIMMUNE turnkey solution offers reasonable cost per sample analysis.
The DOSIMMUNE kit is:
The DOSIMMUNE kit provides a fully validated approach to ISO 17511, with 6 calibrator levels and blank, internal standards and quality controls with 4 levels to simultaneously quantify four key immunosuppressant drugs in whole blood.
The kit also comes with mobile phases, system cleaning phase, extraction & reconstitution buffer, and analytical & trap columns as a complete ready to use solution!
Exceptional Throughput
The combination of LC-MS/MS, liquid handler and automated sample preparation means real sample results can be delivered in hours, with nearly 900 samples assayed in less than 10 hours.
Many different configurations can be proposed to suit each laboratory, with the number of liquid handlers and LC-MS/MS systems selected to suit throughput.
Shimadzu's superior informatic connections enable automatic sample assay sequences to be simply created. In addition, LabSolutions Insight allows for efficient and easy data processing.
All instruments, software and DOSIMMUNE kit are CE-IVD certified.
