Health of animals, companion and farm ones are important for their and for human life. Living together on limited space can easily transfer illnesses and parasites.
There are many special developed pharmaceuticals for use in veterinary medicine and for prophylaxis against pathogens. At the same time feed additives and antibiotics are often used for faster growth and resistance vs. simple bacteria transmitted diseases.
As applied for human pharmaceuticals, also for veterinary pharmaceuticals guidelines for development, testing and release are applied to ensure a safe use and the harmlessness. Those regulations are under frequent control, new (lower) acceptance levels for residuals are applied and the extensive use of antibiotics or hormones has been reduced step by step.
There are no major differences between human and veterinary pharmaceuticals in how the different steps in development look like. General strategy is somewhat similar: beside classic small molecules, biopharmaceuticals are now in development and already in use for several purposes. And, some relatively old developed pharmaceuticals which are not anymore applied for human purposes are still in use as their effectiveness has been proven in veterinary medicine.
Analytic gets important on several aspects – checking dosage of additives and applied veterinary drugs and verify that residuals in final food are below certain tolerance levels.
For more details about development steps please visit the Pharma & Biopharma webpage.
Analysis of antiparasitic agents using LC-MS
Veterinary pharmaceuticals including antibiotics and hormones are used to prevent disease in livestock, promote growth, and enhance the feed efficiency. Antiparasitic agents are also widely used to eliminate parasites from the alimentary canal. Residual standards are being established for antiparasitic agents as residual levels in meat present similar health problems to antibiotics and hormones. The four components used for this test were 5-hydroxythiabendazole, thiabendazole, flubendazole, and albendazole.
Multi-Residue Veterinary Drug Analysis of >200 Compounds using MRM Spectrum Mode by LC-MS/MS
Veterinary drugs are used for therapeutic, metaphylactic, prophylactic and growth promotion purposes. To provide an assurance that food from animals is safe with regards to residues of veterinary medicines, regulatory authorities have established Maximum Residue Limits (MRL's) for certain drugs in target tissues and animal species. Some pharmacologically active compounds identified by regulatory authorities have been prohibited and their hazardousness at all levels are being considered (EU regulation EC 37/2010; Commission Decision 2003/181/EC; 21CFR Part 556 Tolerances for Residues of New Animal Drugs in Food). In this article, we describe how a triple quadrupole mass spectrometer, which is both highly sensitive and selective, contributes to reducing false positive and false negative reporting when using a measurement mode called MRM Spectrum mode.
Analysis of hormone agents for veterinary medication using LC-MS
We consume fish and meat as part of our normal daily diets and healthy human life would be impossible without nutrition from such foodstuffs. Consequently, not only a stable production and supply but safety of farm products, meat, and fish are demanded. Many agricultural chemicals and veterinary pharmaceuticals are currently used to increase productivity, but their residues in food are a problem. This report describes an analysis example of hormones used for livestock. Hormones are used to promote growth in livestock and their safety is investigated in the same way as antibiotics and antiparasitics. The residual standards are established according to the level harmless to humans.